Dear IZMC course applicants,

As you know, travelling and personal contact restrictions due to the Covid-19 pandemic are currently partially released.

Therefore, The IZMC board members have decided to offer again a hybrid zebrafish and medaka FELASA training course. Participants will be on site for 3 days. Several lectures of the course will be given also in remote with accessibility to the lectures already 15 days before the course on site. The hybrid course will allow to reduce the time during which applicant need to be actually present at KIT. The IZMC 059/17 FELASA certificate will be awarded to the participants at the end of the course after successful completion of a final exam.

The latest Corona Ordinance on Academic Education Operations of the Ministry of Science, Research and Arts of Baden Württemberg of August 23, 2021 (valid as of August 24) states the necessity of providing proof of “3G” (proof of having been vaccinated or tested, or of having recovered) for on-campus courses. This may change according to the regulations of the German government at the time of the course.



International Zebrafish and Medaka Course (IZMC)


Fish models have increasingly gained importance in biomedical research during the last few decades. Particularly two teleost species, zebrafish (Danio rerio) and medaka (Oryzias latipes) have become essential model systems for analyzing gene function in vertebrates. Their suitability for forward genetics especially their small size, the transparency of the embryos and the extra-uterine development made them ideal systems for systematic studies of developmental processes. In the meantime these fish have also provided many disease models that allow the study of pathophysiological processes in real time and at high cellular resolution in the intact embryo.

The Directive 2010/63/EU of the European Parliament and of the Council of Europe demand that persons performing animal experimentation should be adequately trained. Today in Germany, a plethora of courses which follow the FELASA B concept is offered by universities and other research institutions. These courses mainly address research with mice and rats however, work with fish is not covered. In order to train students, graduates, postgraduates and principal investigators in the use of zebrafish or medaka for biomedical research, the European Zebrafish Resource Center at the Karlsruhe Institute of Technology offers a course teaching all relevant topics.

The theory element of this course is presented using online material accessible for participants via the ICMZ website. Theory topics – among others – include legal regulations and guidelines, ethical aspects of animal experimentation (3R, alternative concepts), biology, husbandry, breeding and feeding of zebrafish and medaka, as well as health monitoring and diseases. Other fish models in toxicology and biomedical research will be discussed. The practical elements of the course, will include training in the handling, husbandry, breeding, anesthesia, fin clipping and euthanasia of zebrafish and medaka using the facilities of the EZRC and the associated KIT Institute of Toxicology and Genetics.

The course will be completed with a multiple choice examination. Those who have passed the course and examination successfully will receive a certificate confirming their specific knowledge of zebrafish and medaka as well as their skills to work with these animals meeting the legal requirements.



The International Zebrafish and Medaka Course (IZMC) at KIT is accredited for the functions A, C and D
by FELASA ( under the registration no. F059/17 in June 2017.

Function A Carrying out procedure on animals
Function C Taking care of animals
Function D Euthanasia

The IZMC course covers the following modules according to the EU directive 2010/63/EU

EU directive training Framework -> English.

EU Aus- und Fortbildungsrahmen -> Deutsch.

Core Modules N° 1, 2, 3.1, 4, 5, 6.1
Function Modules N° 3.2, 7, 8
Additional Task Modules N° 23

In addition, some topics of other modules are addressed but not in detail.

For further information on the learning outcomes of the course please see

"Learning outcomes Mapping".


ATF -Certificate possible

An ATF (Akademie für tierärztliche Fortbildung) Certificate can be provided, if requested. The IZMC is accredited by the ATF.


Next courses:


7-9 February 2022 (English)

28-30 March 2022 (German)

23-25 May 2022 (English)

26-28 September 2022 (German)

17-19 October 2022 (Language depending on request)

21-23 November 2022 (Language depending on request)

Register here
European Zebrafish Resource Center (EZRC)

The EZRC offers a zebrafish stock collection.