Dear IZMC course applicants,

As you know, travelling and personal contact are currently restricted because of the Covid-19 pandemic. Therefore, we have had to cancel some of our courses in 2020 and it is presently not possible to host the IZMC 059/17F course in the usual way. In order to provide our applicants with training courses for animal experimentation during this difficult period, we have decided to divide our zebrafish training course (IZMC 059/17F) into two parts: (i) theory-based lectures and (ii) a practical course. This will allow participation in the theory-based part remotely and so will reduce the time during which applicants need to be actually present at KIT. Both parts of the course are semi-independent sections:

Part I (Theory): This part consists of all the theory-based lectures for the required training. It will be based purely on our on-line platform with recorded lectures. This part will be followed by a final exam that will also be held online. Once participants have passed the online exam, they will be awarded with an IZMC certificate.

Part II (Practical): Once the pandemic situation has improved so that travelling and on-site practical training are possible, we will once again host a practical training course. We offer two options: (i) participants may wait until the Corona-restrictions have been relaxed and then attend our practical training at KIT. By taking part in this KIT-based practical course, participants will upgrade their theory-based online training to a full FELASA accredited IZMC 059/17 training and so finally receive a FELASA certificate. (ii) alternatively, participants may decide that the theory-based training is sufficient for their needs or they may decide to participate in another IZMC-independent, locally-hosted practical training course. However, with this second option we will not be able to award a final FELASA certificate. In this case, it would be essential that the applicant contact their local authorities to find out if “theory-only” or separate theory and practical training courses would be acceptable.

Participation in Part I (Theory) plus Part II (Practical) at IZMC:

Participants successfully completing both Part I (Theory) and Part II (Practical) at KIT, will receive a full FELASA certificate for the IZMC 059/17 course covering Function A, C and D. This final certificate will substitute for the IZMC “Theory” certificate that will be awarded to the participants after successful completion of Part I (Theory).

Invoices for each part of the course will be sent separately, 15 days before the specific course starts.


Part I (Theory)

University-associated participants = 300 Euro

Company-associated participants = 500 Euro

Part II (Practical)

University-associated participants = 500 Euro

Company-associated participants = 750 Euro

Announcement of Part I (Theory)  and Part 2 (Practical) courses in 2021

The IZMC Part I (Theory) courses have been suspended for the remainder of 2021. This decision has been taken by the IZMC organizers to permit the IZMC participants who have already successfully completed the online IZMC Part 1 (Theory) course, to complete their course work by attending the second (practical) part of the course before the end of the year, as requested by the FELASA organization.

However, new participants are still invited to register to the IZMC waiting list for the 2022 courses, that we hope will be held again in situ after the release of covid-restrictions.

Possible dates for the 2022 courses will be announced as soon as possible.

The IZMC Part 2 (Practical) courses

The IZMC Part 2 (Practical) courses in 2021 will be held in situ at KIT between September and December 2021 (covid-restriction rules permitting). These practical courses are reserved for participants who have previously already successfully attended the online IZMC Part 1 (Theory) course. Participants belonging to this category will be directly contacted by the IZMC organizers for confirmation of their registration and attendance as soon as possible when the dates of the practical courses have been fixed.





International Zebrafish and Medaka Course (IZMC)


Fish models have increasingly gained importance in biomedical research during the last few decades. Particularly two teleost species, zebrafish (Danio rerio) and medaka (Oryzias latipes) have become essential model systems for analyzing gene function in vertebrates. Their suitability for forward genetics especially their small size, the transparency of the embryos and the extra-uterine development made them ideal systems for systematic studies of developmental processes. In the meantime these fish have also provided many disease models that allow the study of pathophysiological processes in real time and at high cellular resolution in the intact embryo.

The Directive 2010/63/EU of the European Parliament and of the Council of Europe demand that persons performing animal experimentation should be adequately trained. Today in Germany, a plethora of courses which follow the FELASA B concept is offered by universities and other research institutions. These courses mainly address research with mice and rats however, work with fish is not covered. In order to train students, graduates, postgraduates and principal investigators in the use of zebrafish or medaka for biomedical research, the European Zebrafish Resource Center at the Karlsruhe Institute of Technology offers a course teaching all relevant topics.

The theory element of this course is presented using online material accessible for participants via the ICMZ website. Theory topics – among others – include legal regulations and guidelines, ethical aspects of animal experimentation (3R, alternative concepts), biology, husbandry, breeding and feeding of zebrafish and medaka, as well as health monitoring and diseases. Other fish models in toxicology and biomedical research will be discussed. The practical elements of the course, will include training in the handling, husbandry, breeding, anesthesia, fin clipping and euthanasia of zebrafish and medaka using the facilities of the EZRC and the associated KIT Institute of Toxicology and Genetics.

The course will be completed with a multiple choice examination. Those who have passed the course and examination successfully will receive a certificate confirming their specific knowledge of zebrafish and medaka as well as their skills to work with these animals meeting the legal requirements.



The International Zebrafish and Medaka Course (IZMC) at KIT is accredited for the functions A, C and D
by FELASA ( under the registration no. F059/17 in June 2017.

Function A Carrying out procedure on animals
Function C Taking care of animals
Function D Euthanasia

The IZMC course covers the following modules according to the EU directive 2010/63/EU

EU directive training Framework -> English.

EU Aus- und Fortbildungsrahmen -> Deutsch.

Core Modules N° 1, 2, 3.1, 4, 5, 6.1
Function Modules N° 3.2, 7, 8
Additional Task Modules N° 23

In addition, some topics of other modules are addressed but not in detail.

For further information on the learning outcomes of the course please see

"Learning outcomes Mapping".


ATF -Certificate possible

An ATF (Akademie für tierärztliche Fortbildung) Certificate can be provided, if requested. The IZMC is accredited by the ATF.


European Zebrafish Resource Center (EZRC)

The EZRC offers a zebrafish stock collection.